Nominees
Video of the Year
* Amy Winehouse - "Rehab"
* Beyoncé - "Irreplaceable"
* Justice - "D.A.N.C.E."
* Justin Timberlake - "What Goes Around...Comes Around"
* Kanye West - "Stronger"
* Rihanna - "Umbrella" featuring Jay-Z
Male Artist of the Year
* Akon - Don't Matter, I Wanna Love You featuring Snoop Dogg, Smack That featuring Eminem
* Kanye West - "Can't Tell Me Nothing", "Stronger", "Classic (Better Than I've Ever Been" — DJ Premier remix, featuring Nas, KRS-One and Rakim)
* Justin Timberlake - "Let Me Talk To You/ My Love" featuring T.I. and Timbaland, "SexyBack" featuring Timbaland, "What Goes Around...Comes Around"
* T.I. - "Big Things Poppin' (Do It)", "You Know What It Is" featuring Wyclef Jean, "What You Know"
* Robin Thicke - "Can U Believe", "Lost Without U", "Wanna Love You Girl" (remix) featuring Busta Rhymes and Pharrell
Female Artist of the Year
* Amy Winehouse - "Rehab", "You Know I'm No Good"
* Beyoncé - "Irreplaceable", "Beautiful Liar" featuring Shakira
* Fergie - "Big Girls Don't Cry (Personal)", "Glamorous" featuring Ludacris, "Fergalicious" featuring Will.I.Am
* Nelly Furtado - Maneater", "Say It Right"
* Rihanna: "Umbrella" featuring Jay-Z
Best New Artist
* Amy Winehouse - "Rehab" "You Know I'm No Good"
* Carrie Underwood - "Before He Cheats"
* Gym Class Heroes - "Clothes Off" featuring Patrick Stump, "Cupid's Chokehold/Breakfast in America" featuring Patrick Stump
* Lily Allen: "Alfie", "Smile", "LDN"
* Peter Bjorn and John: "Young Folks"
Best Group
* Fall Out Boy - "This Ain't A Scene, It's An Arms Race", "Thnks Fr Th Mmrs"
* Gym Class Heroes - "Clothes Off" featuring Patrick Stump, "Cupid's Chokehold/Breakfast in America" featuring Patrick Stump
* Linkin Park - "What I've Done"
* Maroon 5 - "Makes Me Wonder"
* White Stripes - "Icky Thump"
Most Earthshattering Collaboration
* Akon featuring Eminem - "Smack That"
* Beyoncé feturing Shakira - "Beautiful Liar"
* Justin Timberlake featuring Timbaland - "SexyBack"
* Gwen Stefani featuring Akon - "The Sweet Escape"
* U2 featuring Green Day - "The Saints Are Coming"
Quadruple Threat of the Year
* Beyoncé
* Bono
* Jay-Z
* Justin Timberlake
* Kanye West
Monster Single of the Year
* Avril Lavigne - "Girlfriend"
* Daughtry - "Home"
* Fall Out Boy - "Thnks Fr Th Mmrs"
* Lil' Mama - "Lip Gloss (No Music)"
* T-Pain featuring Yung Joc - "Buy U a Drank (Shawty Snappin')"
* Timbaland featuring Keri Hilson, D.O.E. and Sebastian - "The Way I Are"
* MIMS - "This Is Why I'm Hot"
* Plain White T's - "Hey There Delilah"
* Rihanna featuring Jay-Z - "Umbrella"
* Shop Boyz - "Party Like a Rockstar"
Best Director
* Beyoncé featuring Shakira - "Beautiful Liar" - Director: Jake Nava
* Christina Aguilera - "Candyman" - Directors: Matthew Rolston and Christina Aguilera
* Justin Timberlake - "What Goes Around...Comes Around" - Director: Samuel Bayer
* Kanye West - "Stronger" - Director: Hype Williams
* Linkin Park - "What I've Done" Director: Joseph Hahn
* Rihanna featuring Jay-Z - "Umbrella" - Director: Chris Applebaum
Best Editing in a Video
* Beyoncé and Shakira - "Beautiful Liar" - Editor: Jarett Figl
* Gnarls Barkley - "Smiley Faces" - Editor: Ken Mowe
* Justin Timberlake - "What Goes Around...Comes Around" - Editor: Hollee Singer
* Kanye West - "Stronger" - Editors: Peter Johnson and Corey Weisz
* Linkin Park - "What I've Done" - Editor: Igor Kovalik
Best Choreography in a Video
* Beyoncé and Shakira: "Beautiful Liar" - Choreographer: Frank Gatson
* Chris Brown - "Wall To Wall" - Choreographers: Rich & Tone and Flii Styles
* Ciara: "Like A Boy" - Choreographer Jamaica Craft
* Eve - "Tambourine" - Choreographer: Tahesha Scott
* Justin Timberlake featuring Timbaland - "SexyBack" - Choreographer: Marty Kuldeka
Performers
* Lily Allen
* Chris Brown
* Fall Out Boy
* Foo Fighters
* Rihanna
* Timbaland
* Justin Timberlake
* Kanye West (confirmed to open the show on radio interview and his website)
* Amy Winehouse